Metformin (Glucophage) Herbal equivalent: Berberine Antagonistic pleiotropyMethylation (A look at the body’s clock).Sirtuins Silencing protein protective.NAD Booster molecules:“NR” (nicotinamide riboside)NMN #27 – David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging